Synthesis of New Hydrazone Derivatives and Evaluation of their Efficacy as Proliferation Inhibitors in Human Cancer Cells-Reference-Cited by-同舟云学术

Synthesis of New Hydrazone Derivatives and Evaluation of their Efficacy as Proliferation Inhibitors in Human Cancer Cells

Published:2019-11-18 Issue:8 Volume:15 Page:903-910
ISSN:1573-4064
Container-title:Medicinal Chemistry
language:en
Short-container-title:MC

Author:

Świątek Piotr¹,Saczko Jolanta²,Rembiałkowska Nina²,Kulbacka Julita²

Affiliation:

1. Department of Chemistry of Drugs, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland

2. Department of Molecular and Cellular Biology, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland

Abstract

Background: Hydrazine-hydrazones represent a group of bioactive compounds that display antibacterial, anti-inflammatory, antiviral or anticancer activities. Methods: The group of new derivatives was evaluated by the viability assay in human cancer and normal cells. Results: The dimethylpyridine hydrazones showed potent inhibition of cell proliferation of breast, colon cancer cells, human melanoma and glioblastoma. Compound 12 inhibited proliferation of cancer cells exhibiting a drug-resistant phenotype (MCF-7/DX and LoVoDX) at low millimolar concentrations. Whereas, antimelanoma activity was revealed by Compounds 2, 4, 7 and 12. Conclusion: The present results highlighted newly synthetized hydrazine derivatives an excellent base for the design of new anticancer agents and resistance inhibitors.

Funder

Wroclaw Medical University

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery

Reference26 articles.

1. Okon I.S.; Zou M-H.; Mitochondrial ROS and cancer drug resistance: Implications for therapy. Pharmacol Res 2015,100,170-174

2. Holohan C.; Van Schaeybroeck S.; Longley D.B.; Johnston P.G.; Cancer drug resistance: an evolving paradigm. Nat Rev Cancer 2013,13(10),714-726

3. Kumar D.; Maruthi Kumar N.; Ghosh S.; Shah K.; Novel bis(indolyl)hydrazide-hydrazones as potent cytotoxic agents. Bioorg Med Chem Lett 2012,22(1),212-215

4. Vicini P.; Incerti M.; Doytchinova I.A.; La Colla P.; Busonera B.; Loddo R.; Synthesis and antiproliferative activity of benzo[d]isothiazole hydrazones. Eur J Med Chem 2006,41(5),624-632

5. Yu X.; Shi L.; Ke S.; Acylhydrazone derivatives as potential anticancer agents: Synthesis, bio-evaluation and mechanism of action. Bioorg Med Chem Lett 2015,25(24),5772-5776

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