Affiliation:
1. Research and Development, Jamjoom Pharmaceuticals, Jeddah21442, Saudi Arabia
Abstract
Introduction:
Conventional enteric coating is very challenging in soft gel capsules because
of their shell nature (smooth surfaces and elasticity). Soft gelatin capsules are highly sensitive
to temperature, humidity and they can lose their tensile strength during the conventional coating
process.
Materials and Methods:
Enteric soft gel capsules were prepared by the addition of enteric polymer
in the gelatin shell composition by inducing the cross-linking of gelatin through chemical treatment.
Results:
This dual approach makes the soft gelatin capsules resist the drug release in the stomach
and reliably release their contents in the intestine within a predetermined time without affecting the
physical properties of soft gel capsules.
Conclusions:
Enteric effects of soft gel capsules are brought by a specialized synergetic technique,
which is unique for the molecules, requiring intestinal drug release.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology, Toxicology and Pharmaceutics (miscellaneous),Pharmaceutical Science,Biomedical Engineering