Novel Strategies and Model Studies for Colon Targeted Drug Delivery

Abstract

: Targeting drugs with controlled release characteristics to the colon is gaining importance for localized action as well as to improve the systemic availability of peptides and proteins. : The present manuscript aims to describe the various approaches and model study for colon targeted drug delivery. : Drugs that have low absorption window are targeted into in the colonic regions using different novel technologies such as microparticulate system, prodrugs, pH and time dependent polymeric, effervescent and noneffervescent systems etc. Along with this it manuscript also describes the model study for colon targeting. : Colon targeted drug delivery system offers the potential therapeutic benefits to patients in terms of both local and systemic treatment. These drugs can be directly targeted in the colon which helps in the reducing systemic side effects.