Development and Evaluation of Exenatide Loaded PLGA Nanoparticles
for Intranasal Delivery in the Treatment of Obesity
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Published:2022-06
Issue:2
Volume:12
Page:149-162
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ISSN:2210-3031
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Container-title:Drug Delivery Letters
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language:en
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Short-container-title:DDL
Author:
Pandya Tosha12ORCID, Bhatt Priyanka3, Misra Ambikandan1
Affiliation:
1. Department of Pharmacy, Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Kalabhavan Campus, Vadodara 390001, Gujarat, India 2. L.J. Institute of Pharmacy, S.G. Highway, Sanand Circle, Sarkhej, Ahmedabad, Gujarat 3882210, India 3. Department of Pharmaceutical Sciences, Wegmans School of Pharmacy, St. John Fisher College, Rochester, NY, USA
Abstract
Background:
Obesity, considered a complex condition, is the fastest-growing public health concern worldwide. Its treatment is limited due to the side effects of pharmacological options available, outweighing their benefits.
Aim:
The present study aims to formulate a novel biodegradable formulation of exenatide for direct brain delivery through the nasal route.
Methods:
To formulate exenatide loaded poly (lactide-co-glycolide) (PLGA) nanoparticles, a dou-ble emulsion (w/o/w) solvent evaporation method was employed. A full factorial (33) design of the experiment was used to optimize the formulation.
Results:
The entrapment efficiency and particle size of the optimized formulation were found to be 68% and 110 nm, respectively. The in-vitro drug release study indicated the sustained release of 48% drug in 5 days. The safety of drug-loaded PLGA nanoparticles for intranasal delivery was in-dicated by the sheep nasal toxicity study. The efficacy of the developed nanoparticles was demon-strated by an in-vivo pharmacodynamics study on Albino Wistar rats, showing a 6.2% weight reduc-tion after 30 days of treatment.
Conclusion:
Thus, exenatide is a novel peptide having significant weight loss benefits and no se-vere side effects. Long-term studies in at least two or more animal models followed by extensive clinical evaluation can safely result in a product for clinical use.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology, Toxicology and Pharmaceutics (miscellaneous),Pharmaceutical Science,Biomedical Engineering
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