A Comprehensive Review on Nanotechnological Approaches for Enhanced Delivery of Nutraceuticals in the Management of Osteoporosis

Abstract

Abstract: Osteoporosis is a chronic, progressive bone condition that is most prevalent in postmen-opausal women and the elderly population. An imbalance in the natural bone remodeling process, which is involved in the formation of bone and resorption, is responsible for osteoporosis, leading to bone fragility. It shows no clinical manifestation until a fracture takes place. Osteoporosis is a glob-al epidemic that reduces the quality of life, increases the chances of disabilities, and adds on a huge financial load. Early diagnosis and treatment can help in preventing the disease. Several drug regi-mens are used in treating the condition; however, the drugs are accompanied by several adverse ef-fects. Nutraceuticals, like herbs, minerals, vitamins, and dairy products, support skeletal strength and integrity. Therefore, the use of different types of nutraceuticals can improve overall bone strength and provide improved treatment of osteoporosis. The review paper focuses on providing in-depth knowledge about the various nutraceuticals that are used in the management of osteoporosis along with the novel nanotechnology-based delivery approaches for enhanced delivery of nutraceu-ticals as the advent of nanotechnology in pharmaceuticals have opened new avenues in the chal-lenging arena of nutraceuticals for providing benefits like stability, higher efficiency, solubility, en-hanced bioavailability, permeability, and production without additives.