Affiliation:
1. University Institute of Pharma Sciences, Chandigarh University, Gharuan, Mohali (140413), India
2. University Centre for Research and Development, Chandigarh University, Gharuan, Mohali (140413), India
Abstract
Abstract:
This mini-review article focuses on the recent advancements in nano-biosensors for
the detection of epigenetic changes, a burgeoning field at the intersection of nanotechnology and
cancer diagnostics. Epigenetic modifications, including DNA methylation, histone modification,
and non-coding RNA expression, play a crucial role in cancer progression and drug resistance.
The advent of nano-biosensors has introduced highly sensitive and specific methods for detecting
these changes, surpassing the capabilities of traditional diagnostic tools. This article delves
into various nano-biosensors, such as gold nanoparticles, quantum dots, carbon nanotubes, and
graphene oxide sensors, highlighting their unique properties and applications in detecting epigenetic
markers. It emphasizes the significance of early and accurate detection of epigenetic alterations
in cancer, which opens new pathways for early diagnosis, monitoring treatment efficacy,
and developing personalized therapeutic strategies. The review also addresses the technical challenges
and limitations of current nano-biosensor technologies, including issues related to sensitivity,
specificity, and biocompatibility. Furthermore, it explores the ethical and safety considerations
in the clinical application of these nanotechnologies. The discussion extends to the potential
future developments in this field, emphasizing interdisciplinary research and the integration
of artificial intelligence for data analysis. This comprehensive overview of nano-biosensors for
epigenetic change detection underscores their transformative potential in cancer research, offering
insights into their current state, challenges, and future prospects in advancing personalized
cancer care.
Publisher
Bentham Science Publishers Ltd.