Association between Oxidative Balance Score and Severe Headache or Migraine among American Adults A Cross-Section Study

Author:

Geng Dandan1ORCID,Liu Huanxian2ORCID,Wang Haoyuan3ORCID,Dong Zhao24ORCID,Wang Hebo15ORCID

Affiliation:

1. Department of Neurology, Hebei General Hospital affiliated to Hebei Medical University, Shijiazhuang, Hebei, China

2. Department of Neurology, Chinese PLA General Hospital, Beijing, China

3. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

4. International Headache Center, Chinese PLA General Hospital, Beijing, China

5. Hebei Key Laboratory of Cerebral Network and Cognitive Disorders, Shijiazhuang, Hebei, China

Abstract

Background: Migraine is implicated in oxidative stress. The oxidative balance score (OBS) assesses the combined impact of diet and lifestyle on oxidative and antioxidant balance in diseases. However, the association between OBS and migraine remains underexplored. Objective: We aimed to examine the relationship between OBS and severe headaches or migraines among American adults Methods: This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) 1999-2004, defining severe headaches or migraine via self-reports and calculating OBS from 16 diaries and 4 lifestyle factors. Multivariable weighted logistic regression models were used to explore the OBS-migraine relationship, with stratified analysis for result validation. Results: The study included 6,653 participants (average age 45.6, 52.1% male), and 19.1% reported severe headaches or migraines. There was a significant inverse association between OBS and severe headache or migraine, with an adjusted odds ratio (OR) of 0.97 (95% [confidence interval] CI: 0.96, 0.98, p < 0.001). The highest OBS tertile had an adjusted OR of 0.58 (95% CI: 0.47, 0.73) compared to the lowest. This pattern was consistent across sexes, with an adjusted OR of 0.98 (0.95, 1.00) in males and 0.97 (0.95, 1.00) in females. The adjusted OR for migraine was 0.61 (0.44, 0.87) and 0.54 (0.37, 0.79) in the highest tertile for males and females, respectively. Conclusion: The study highlights a significant association between OBS and severe headaches or migraines, suggesting the potential role of oxidative stress in these conditions. The findings emphasize the importance of a balanced, antioxidant-rich diet and lifestyle in managing severe headaches or migraine.

Publisher

Bentham Science Publishers Ltd.

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