Affiliation:
1. Shandong University of Traditional Chinese Medicine First Clinical Medical College Jinan China
2. Affiliated Hospital of Shandong University of Traditional Chinese Medicine Department of Neurology Jinan China
Abstract
Abstract::
With the acceleration of people's pace of life, non-alcoholic fatty liver disease (NAFLD)
has become the most common chronic liver disease in the world, which greatly threatens people's
health and safety. Therefore, there is still an urgent need for higher-quality research and treatment in
this area. Nuclear factor Red-2-related factor 2 (Nrf2), as a key transcription factor in the regulation
of oxidative stress, plays an important role in inducing the body's antioxidant response. Although
there are no approved drugs targeting Nrf2 to treat NAFLD so far, it is still of great significance to
target Nrf2 to alleviate NAFLD. In recent years, studies have reported that many natural products
treat NAFLD by acting on Nrf2 or Nrf2 pathways. This article reviews the role of Nrf2 in the pathogenesis
of NAFLD and summarizes the currently reported natural products targeting Nrf2 or Nrf2
pathway for the treatment of NAFLD, which provides new ideas for the development of new
NAFLD-related drugs.
Publisher
Bentham Science Publishers Ltd.
Cited by
3 articles.
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