Predicting Futile Recanalization in Acute Ischemic Stroke Patients Undergoing Endovascular Thrombectomy: The Role of White Blood Cell Count to Mean Platelet Volume Ratio

Author:

Yu Wantong12,Jia Milan1,Guo Wenting1,Xu Jiali1,Ren Changhong2,li Sijie23,Zhao Wenbo12,Chen Jian4,Duan Jiangang3,Ma Qingfeng1,Song Haiqing1,Ji Xunming4152

Affiliation:

1. Department of Neurology, Xuanwu Hospital, Capital Medical University Beijing, China

2. Beijing Key Laboratory of Hypoxia Translational Medicine, Xuanwu Hospital, Capital Medical University Beijing, China

3. Department of Emergency, Xuanwu Hospital, Capital Medical University, Beijing, China

4. Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China

5. Center of Stroke, Beijing Institute for Brain Disorder, Capital Medical University, Beijing, China

Abstract

Background:: Approximately half of AIS patients have an unfavorable outcome even after complete reperfusion. White blood cell (WBC) count to mean platelet volume (MPV) ratio (WMR) may be a promising predictive factor for futile recanalization. This study aimed to determine the predictive value of WMR in identifying individuals at higher risk of futile recanalization. Methods:: In this retrospective cohort study, 296 patients who achieved complete reperfusion after endovascular treatment (EVT) were included in the analysis. WBC count and MPV were collected at admission. Multivariable logistic regression was used to examine the independent association of the WMR with functional outcomes at three months. Net reclassification improvement (NRI) and integrated discrimination improvement (IDI) analyses were used to compare the accuracy of WMR for predicting futile recanalization. Results:: The adjusted odds ratios for the fourth quartile of WMR were 3.142 (95% CI 1.405- 7.027, P = 0.005) for unfavorable outcomes at 3 months in comparison with the first quartile. The inclusion of WMR in the traditional model enabled a more accurate prediction of unfavorable outcomes (NRI 0.250, P = 0.031; IDI 0.022, P = 0.017). Conclusion:: Elevated WMR at admission was independently associated with futile recanalization among AIS patients who received EVT and might be useful in identifying futile recanalization.

Publisher

Bentham Science Publishers Ltd.

Subject

Cellular and Molecular Neuroscience,Developmental Neuroscience,Neurology,Neurology (clinical)

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