The Association between Vitamin D Deficiency and Changes in Cognitive Functions in Chinese Older Adults: A Prospective Cohort Study-Reference-Cited by-同舟云学术

The Association between Vitamin D Deficiency and Changes in Cognitive Functions in Chinese Older Adults: A Prospective Cohort Study

Published:2023-07 Issue:7 Volume:20 Page:506-514
ISSN:1567-2050
Container-title:Current Alzheimer Research
language:en
Short-container-title:CAR

Author:

Li Tongtong¹^ORCID,Chen Chong²,Yuan Jing¹,Zhang Keming³,Zhang Meilin⁴,Zhao Huichao⁵,Wu Xiaomin¹,Zhu Liping¹,Huang Guowei⁴,Ma Fei¹

Affiliation:

1. Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Key Laboratory of Environment, Nutrition and Public Health, Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, 300070, China

2. Department of Clinical Laboratory, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjinʼs Clinical Research Center for Cancer, National Human Genetic Resources Sharing Service Platform, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China

3. Department of Nutrition, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300073, China

4. Department of Nutrition and Food Science, School of Public Health, Tianjin Key Laboratory of Environment, Nutrition and Public Health, Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, 300070, China

5. Department of Medicine and Humanities, Tianjin Medical University, Tianjin, 300070, China

Abstract

Background:: Along with the problem of population aging, the prevalence of dementia is gradually increasing. Associations between vitamin D deficiency (VDD) and cognitive functions remains controversial. Objectives:: We aimed to determine the relationship between VDD and changes in cognitive performance in community-dwelling older adults. Methods:: In this longitudinal cohort study, Chinese participants aged ≥65 years were enrolled in March 2016. The serum level of 25-hydroxy-vitamin D was analyzed by liquid-chromatography-tandem-mass-spectrometry at baseline. VDD was defined as less than 20ng/mL. All participants accomplished a health status questionnaire. Cognitive functions were evaluated by Wechsler Adult Intelligence Scale-Revised in China at baseline and each visit. The linear mixed-effects model was utilized to examine the association between baseline VDD and changes in cognitive functions. Results:: In total, 866 participants were included in our study, with a mean duration of 3 years. VDD was markedly associated with lower full intelligence quotient (FIQ) (β: -3.355, 95% confidence interval [CI]:-4.165,-2.545), verbal intelligence quotient (VIQ) (β: -3.420, 95%CI: -4.193,-2.647), performance intelligence quotient (PIQ) (β: -2.610, 95%CI: -3.683,-1.537), comprehension (β: -0.630, 95%CI: -1.022,-0.238), information (β: -0.354, 95%CI: -0.699,-0.008), arithmetic (β: -1.065, 95%CI: -1.228,-0.902), digit span (β: -0.370, 95%CI: -0.547,-0.192), vocabulary (β: -0.789, 95%CI: -1.083,-0.493), picture completion (β: -0.391, 95%CI: -0.761,-0.022), block design (β: -0.412, 95%CI: -0.697,-0.127), picture arrangement (β: -0.542, 95%CI: -0.909,-0.174) and object assembly (β: -0.492, 95%CI: -0.818,-0.165) than those with adequacy. Conclusion:: A higher frequency of VDD was associated with lower scores of FIQ, VIQ, PIQ and subtests on memory and executive function. Future randomized controlled trials are warranted to further verify the conclusions

Funder

National Natural Science Foundation of China

International Cooperation National Natural Science Foundation of China

Publisher

Bentham Science Publishers Ltd.

Subject

Neurology (clinical),Neurology

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