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5. The 12 principles of green chemistry are: (i) prevention, (ii) atom economy, (iii) less hazardous chemical synthesis, (iv) designing safer chemicals, (v) designing safer solvents, (vi) energy efficiency, (vii) use of renewable feedstocks, (viii) avoid protection and deprotection, (ix) use of catalyst, (x) design chemicals to degrade after use, (xi) analyse in real-time to prevent pollution, and (xii) safer chemistry to avoid accidents.