Affiliation:
1. School of Chemistry, Damghan University, Damghan, Iran
Abstract
Background:
1-Amidoalkyl-2-naphthols are an attractive group of organic compounds
that can be converted to oxazine heterocycles and aminoalkyl naphthols. The derivatives of 1-
amidoalkyl-2-naphthols have significant biological activities and act as drug candidates.
Methods:
1-Amidoalkyl-2-naphthols were synthesized via the three-component condensation reaction
of 2-naphthol, acetamide/benzamide and various aldehydes in the presence of 10 mol% of adipic
acid as an organocatalyst under solvent-free conditions at 120°C.
Results:
A simple, efficient, and operative method for the synthesis of 1-amidoalkyl-2-naphtholes in
the presence of adipic acid as the biodegradable catalyst is introduced. Easy operation, acceptable reaction
times, eco-friendly, availability of starting materials, simple separation of products, and high
yields of products are the significant results of this method.
Conclusion:
In this study, 1-amidoalkyl-2-naphthols were synthesized using commercially available
reactants in excellent yields and relatively shorter times. In this process, microwave or ultrasonic
waves were not used to provide energy for the reaction.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Analytical Chemistry,Catalysis
Cited by
13 articles.
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