Potential uses of Topical Resiquimod for Mycosis Fungoides Tumor Stage

Abstract

Introduction: Resiquimod (formula C17H22N4O2, ChEMBL Id 383322) is an immune response modifier that stimulates immune responses to tumor lesions mostly through toll-like receptors (TLR) 7 and 8 dependent pathways. Methods: This study considers the potential use of Resiquimod in the topical treatment of myco-sis fungoides tumor stage, for which standard-of-care is radiation therapy which has a very well-known dosage-effects relationship and efficacy, but also side effects, and also the limitation re-garding the number of times a same area can be treated during a lifetime. Result: Trials are suggested to evaluate the use of Resiquimod as a replacement for radiation therapy in case of shallow lesions, as well as a supporting agent to increase the efficacy and re-duce the dosage of the radiation therapy, lessening the side effects, and permitting many more uses for a same treatment zone. Conclusion: This study proposes more research for the possible use of Resiquimod in the standalone or synergetic treatment of MF tumor phase, as there is potential, but not yet evidence, for these uses.