Affiliation:
1. School of Sciences, Xi`an University of Technology，Xi’an, 710054, China
Abstract
Background:
The synthesis of 5-arylation uracil nucleosides is an imperative challenge,
especially for the method of Suzuki reaction using N-unprotected uracil as materials, which holds
the potential to enhance the yield.
Objective:
The objective of the study was to find a more efficient catalyst to increase the yield of
aryluracils and aryluridines.
Methods:
We first constructed the phosphanamine-grafted cellulose (PAGC) from cellulose material.
Then, we prepared the nanocatalyst PAGC/Pd(0) through heating and reducing the mixture of
PAGC and Pa(OAc)2.
Results:
When using this nanocatalyst to catalyze the Suzuki reaction of 5-iodouracil or 5-iodouridine
and aryl heterocyclic boronic acids, the arylation yields have been significantly improved.
Conclusion:
This means that the resultant nanocatalyst exhibits a remarkable catalytic efficacy for
Suzuki arylation of 5-iodouracil and 5-iodouridine.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Analytical Chemistry,Catalysis