Ultrasound-Promoted Sustainable Synthesis and Antimicrobial Evaluation of 2-Aryl Benzimidazoles Catalyzed by BPAE at Room Temperature

Abstract

Background: Present-day chemists are more interested in developing and using green chemistry protocol for various organic transformations, which employ natural feedstock extracts, and solvent-free, and greener catalysts; they are well known for their non-hazardous nature and have replaced many organic and inorganic based catalysts. In literature, the reported homogenous catalytic approaches have been employed for various bioactive heterocycle syntheses, which follow the green chemistry principle established for various organic transformations catalyzed by WERSA, BFE, WEPPA, WEMFSA, WEMPA, and Eichhorniacrassipes. Among them, 2-aryl benzimidazole derivatives have emerged as prominent molecules with a wide variety of applications in biological and material science. Methods: The agro-waste sourced from the banana peel is utilized for the preparation of BPAE catalyst, which is employed for the synthesis of 2-aryl benzimidazole derivatives under ultrasound waves at room temperature. Results: Here, 2-Aryl benzimidazoles synthesized through the reaction of a substituted o-phenylene diamine with substituted benzoyl chloride catalyzed by BPAE under ultrasound waves at room temperature are described. Furthermore, catalyst BPAE is characterized by flame emission spectrometry, SEM-EDX, and XRD techniques. Conclusion: The present work established an eco-friendly, sustainable and novel approach for the synthesis of 2-aryl benzimidazoles using natural feedstock BPAE. The major merits of BPAE include its use as an agro-waste-derived catalyst. It is also highly abundant, inexpensive, yields faster reactions, has a simple workup, and does not require the use of column chromatography.