Affiliation:
1. Laboratoire de Développement Chimique, Galénique et Pharmacologique des Médicaments (LR12ES09), Université de Monastir, Faculté de Pharmacie de Monastir, Rue Avicenne, 5000, Monastir, Tunisia
Abstract
Background:
Acetylation of protic nucleophiles is used to protect these functional groups. Most of the methods
described in the literature use solvents, one equivalent or more of toxic bases or expensive and toxic catalysts. Therefore,
new methodologies are still in demand, above all, greener and more economical procedures.
Objective:
An eco-efficient method developed for acetylation of alcohols, phenols, thiols, amines and carbohydrates, using acetic anhydride and a catalytic amount of the environmentally benign and inexpensive FeCl3.6H2O under solvent
free conditions.
Methods:
Acetylation of a variety of protic nucleophiles was performed using 0.2 mol % of FeCl3.6H2O as the catalyst,
and 1.2 equiv. as the acetylating agent at room temperature and under solvent free conditions.
Results:
Our procedure appears to be highly efficient and promoted rapid and quantitative acetylation under simple and
minimum manipulation. Chromatography or recrystallization were generally not necessary for the purification of products.
Conclusion:
This eco-friendly protocol appears to be potentially universally applicable in organic design to protect protic
nucleophiles and potentially scalable for industrial fields.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Analytical Chemistry,Catalysis
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献