Affiliation:
1. Centre for Molecular Biology, Central University of Jammu, Jammu (J&K), India
2. Department of ENT and Head &
Neck Surgery, Acharya Shri Chander College of Medical Sciences and Hospital (ASCOMS), Jammu (J&K), India
Abstract
Abstract:
Cancer is one of the compelling and pegged diseases battled by clinicians and researchers
worldwide. Among different types of cancer, oral cancer holds the sixth position globally. With an
escalating prevalence in Asian countries, India, China, and Pakistan constitute a large proportion of
total incidents of oral cancer patients in terms of new cases or deaths. This mounting prevalence is
ascribed to poor oral hygiene and rampant use of substances earmarked as potential risk factors for
the disease. Risk factors (dietary/lifestyle habits/occupational/environmental) trigger the activation of
oncogenes, dysregulation of lncRNA and miRNA, and silence the tumor suppressor genes, which
robustly contributes to the onset and progression of tumorigenesis in oral squamous cell carcinoma.
Evidence suggests that specific carcinogens identified in tobacco and related products alter many
cellular pathways predisposing to advanced stages of oral cancer. Long non-coding RNAs represent a
broad group of heterogenous transcripts longer than 200 nucleotides which do not translate to form
functional proteins. They regulate various cellular pathways by specifically interacting with other
RNAs, DNA, and proteins. Their role in the pathogenesis of OSCC and other cancer is still being
debated. In this review, we discuss the molecular insights of significant lncRNAs involved in some
crucial deregulated pathways of tobacco-associated OSCC. The implications and challenges to
harnessing the potential of lncRNAs as biomarkers in early diagnosis and targeted treatment have also
been analyzed.
Publisher
Bentham Science Publishers Ltd.
Subject
Cancer Research,Drug Discovery,Pharmacology,Oncology
Cited by
5 articles.
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