Affiliation:
1. School of Computational and Integrative Sciences, Jawaharlal Nehru University New Delhi, India
Abstract
Head and neck squamous cell carcinoma (HNSCC) continues to be a global public health burden even after a
tremendous development in its treatment. It is a heterogeneous cancer of upper aero-digestive tract . The contemporary
strategy to treat cancer is the use of anticancer drugs against proteins possessing abnormal expression. Targeted
chemotherapy was found successful in HNSCC but still, there is a stagnant improvement in the survival rates and high
recurrence rates due to undesirable chemotherapy reactions, non-specificity of drugs, resistance against drugs and drug
toxicity on non-cancerous tissues and cells. Various extensive studies lead to the identification of drug targets capable to
treat HNSCC effectively. The current review article gives an insight into these promising anticancer targets along with
knowledge of drugs under various phases of development. In addition, new potential targets that are not yet explored against
HNSCC are also described. We believe that exploring and developing drugs against these targets might prove beneficial in
treating HNSCC.
Publisher
Bentham Science Publishers Ltd.
Subject
Cancer Research,Drug Discovery,Pharmacology,Oncology
Cited by
13 articles.
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