Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of Cancer-Reference-Cited by-同舟云学术

Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of Cancer

Published:2019-04-24 Issue:5 Volume:19 Page:360-367
ISSN:1568-0096
Container-title:Current Cancer Drug Targets
language:en
Short-container-title:CCDT

Author:

Chen Junsong¹,Niu Na²,Zhang Jing³,Qi Lisha²,Shen Weiwei²,Donkena Krishna Vanaja²,Feng Zhenqing¹,Liu Jinsong²

Affiliation:

1. Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu, China

2. Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States

3. State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China

Abstract

Polyploidy is associated with increased cell size and is commonly found in a subset of adult organs and blastomere stage of the human embryo. The polyploidy is formed through endoreplication or cell fusion to support the specific need of development including earliest embryogenesis. Recent data demonstrated that Polyploid Giant Cancer Cells (PGCCs) may have acquired an activated early embryonic-like program in response to oncogenic and therapeutic stress to generate reprogrammed cancer cells for drug resistance and metastasis. Targeting PGCCs may open up new opportunities for cancer therapy.

Funder

National Cancer Institute Cancer Center

Publisher

Bentham Science Publishers Ltd.

Subject

Cancer Research,Drug Discovery,Pharmacology,Oncology

Reference62 articles.

1. Cronin KA, Lake AJ, Scott S, Sherman RL, Noone AM, Howlader N, Henley SJ, Anderson RN, Firth AU, Ma J, Kohler BA, Jemal A. Cancer, Annual report to the nation on the status of cancer, Part I: National Cancer Statistics., 2018, , -,

2. Weinberg RA. Cell, Coming full circle-from endless complexity to simplicity and back again., 2014, 157, 267-271,

3. Davoli T, de Lange T. Annu Rev Cell Dev Biol, The causes and consequences of polyploidy in normal development and cancer., 2011, 27, 585-610,

4. Fox DT, Duronio RJ. Development, Endoreplication and polyploidy: Insights into development and disease., 2013, 140, 3-12,

5. Orr-Weaver TL. Trends Genet, When bigger is better: The role of polyploidy in organogenesis., 2015, 31, 307-315,

Cited by 125 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Amitotic Cell Division, Malignancy, and Resistance to Anticancer Agents: A Tribute to Drs. Walen and Rajaraman;Cancers;2024-09-08

2. A Fungicide, Fludioxonil, Formed the Polyploid Giant Cancer Cells and Induced Metastasis and Stemness in MDA-MB-231 Triple-Negative Breast Cancer Cells;International Journal of Molecular Sciences;2024-08-20

3. Cells in the Polyaneuploid Cancer Cell State are Pro-Metastatic;2024-07-16

4. Polyploid giant cancer cells induced by Docetaxel exhibit a senescence phenotype with the expression of stem cell markers in ovarian cancer cells;PLOS ONE;2024-07-11

5. Changing the Landscape of Solid Tumor Therapy from Apoptosis-Promoting to Apoptosis-Inhibiting Strategies;Current Issues in Molecular Biology;2024-05-28