Antidiabetic Agents from Fungi with Special Reference to α-Glucosidase Inhibitors

Author:

Deshmukh Sunil Kumar1ORCID,Gupta Manish Kumar2,Agrawal Shivankar34

Affiliation:

1. Research and Development Division, Greenvention Biotech Pvt. Ltd., Uruli-Kanchan, Pune-412202, Maharashtra, India

2. SGT College of Pharmacy, SGT University, Gurugram-122505 (HR), India

3. Department of Phytochemistry, National Institute of Traditional Medicine, Indian Council of Medical Research (ICMR), Belgaun, India

4. Department of Health Research (Government of India), Nehru Nagar, Belagavi, Karnataka, India

Abstract

: The enzyme α-glucosidases (EC 3.2.1.20) catalyzes the hydrolysis of α-1,4-glucopyranoside bond in oligosaccharides and disaccharides and thus plays an essential role in regulating glucose content and the level of postprandial hyperglycemia. The inhibition of α-glucosidases is considered a viable strategy to develop new and effective antidiabetic drugs. Many patents like ZA201905405B; US9073897B2 have been published on α-glucosidase inhibitors. In recent years, several classes of fungal-metabolites possessing a varying degree of α-glucosidases inhibitory activity have been reported. The primary chemical classes include xanthone, phenanthrene, terpenoid, coumarin, isocoumarin, naphthalene, piperazine, and polyketides. Few of the identified inhibitors exhibited severalfold better activities than well-known α-glucosidases inhibitor acarbose and can be used as a lead to develop new antidiabetic drugs. The present review highlights the recent development in the identification of α-glucosidases inhibitors from various fungal sources. Their chemical class, structures, and inhibitory activity in terms of IC50 or MIC are discussed here.

Publisher

Bentham Science Publishers Ltd.

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3