Affiliation:
1. Department of Pharmaceutical Science and Technology, Madan Mohan Malaviya University of Technology, Gorakhpur,
Uttar Pradesh, India
Abstract
Background:
Lipid nanocarriers (NLCs) have undergone significant research over the past
two decades to determine how well they target drugs to important parts of the human body, such as the
central nervous system (CNS), the heart region, tumor cells, etc.
Objective:
The objective of this review paper was to review and critically summarize recent progress
in NLC for targeting CNS.
Methods:
The structure, classification, elements, and numerous preparation techniques have been carefully
outlined in this paper, along with their benefits and drawbacks, as demonstrated by several research
investigations.
Results:
This review focuses on recent developments in NLCs for brain targeting of bioactives with
special attention to their surface modifications, formulation aspects, pharmacokinetic behavior, and effectiveness
for treating a variety of brain disorders.
Conclusion:
Poorly water-soluble bioactive substances’ physicochemical properties and behavior,
such as aqueous dispersibility and oral bioavailability, can be greatly improved using lipid nanocarriers.
Due to the brain's complicated structure and numerous protective systems, drug distribution to the
brain has remained a difficult problem for scientists. The employment of an appropriate nanocarrier
technology and an alternate drug delivery method, such as nose-to-brain drug delivery, could overcome
the problem of brain targeting and increase the therapeutic effectiveness of CNS-acting medications.
The pharmaceutical business has recently transformed various innovative drug delivery methods
that address the drawbacks of conventional drug delivery systems and offer a good benefit-to-risk ratio.
Publisher
Bentham Science Publishers Ltd.
Subject
Building and Construction
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