Pharmacokinetic Aspects of Carbon Nanotubes: Improving Outcomes of Functionalization
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Published:2019-07-19
Issue:5
Volume:>15
Page:454-459
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ISSN:1573-4137
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Container-title:Current Nanoscience
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language:en
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Short-container-title:CNANO
Author:
Entezar-Almahdi Elaheh1, Morowvat Mohammad Hossein1
Affiliation:
1. Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, P.O. Box 71345-1583, Shiraz, Iran
Abstract
Background:
Carbon nanotubes (CNTs) are allotropes of carbon with a cylindrical nanostructure.
Thanks to their electrical, mechanical and optical properties, they have been widely used for
different pharmaceutical, biological and biomedical applications. To understand the biofate of the
CNTs in the body, their pharmacokinetic properties should be revealed appropriately.
Objective:
To review the available literature, regarding the different pharmacokinetic properties including
absorption, distribution, metabolism and elimination of the functionalized CNTs.
Results:
Surface coating or functionalizing the CNTs has huge effects on their pharmacokinetics,
ADME properties and also their biodistribution profile. During the metabolism, CNTs could be destroyed
directly or their surface functional groups might be removed. Both biliary and renal pathways
are known for CNTs elimination.
Conclusion:
Additional optimization on the CNTs formulation is required to enhance their absorption
and bioavailability. Besides, regarding the increased scientific attention towards the CNTs toxicity,
it could be suggested that determining the bioavailability of CNTs is a critical parameter to determine
the CNTs safety.
Funder
Research Deputy of Shiraz University of Medical Sciences, Shiraz, Iran
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering,Biotechnology
Reference61 articles.
1. Boczkowski J, Lanone S. Nanomedicine, Potential uses of carbon nanotubes in the medical field: How worried should patients be?,, 2007, 2,, 407-410, 2. Beg S, Rizwan M, Sheikh AM, Hasnain MS, Anwer K, Kohli K. J Pharm Pharmacol, Advancement in carbon nanotubes: Basics, biomedical applications and toxicity.,, 2011, 63,, 141-163, 3. De Volder MF, Tawfick SH, Baughman RH, Hart AJ. Science, Carbon nanotubes: Present and future commercial applications.,, 2013, 339,, 535-539, 4. Iijima S. Nature, Helical microtubules of graphitic carbon.,, 1991, 354,, 56-58, 5. Amenta V, Aschberger K. Wiley Interdiscip Rev Nanomed Nanobiotechnol, Carbon nanotubes: Potential medical applications and safety concerns.,, 2015, 7,, 371-386,
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