Recent Advances of Nanotechnology in Brain Targeting

Abstract

Abstract: Central nervous system disorders, particularly neurodegenerative disorders, are a serious public health concern that researchers must address to protect the persons against them. The prevalence of the blood-brain barrier (BBB), which segregates the blood from cerebral parenchyma and hence limits the brain uptake of most of the therapeutic agents, makes developing drug delivery systems for brain delivery one of the most challenging research subjects in pharmaceutical domains. The detailed description of BBB-crossing nanotechnology in this article is expected to pique the attention of researchers from a wide range of fields who want to help build powerful BBB-crossing nanosystems for highly effective brain targeting. Recent advances in nanotechnology have resulted in multifunctional nanosystems that can cross or circumvent the BBB, allowing for more accurate assessment and treatment of brain tumours. The application of nanotechnology in targeting different drugs across the brain is included in this review.