Affiliation:
1. Medical Bionanotechnology, Faculty of Allied Health Sciences, Chettinad Hospital & Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Kelambakkam, Chennai-603 103, INDIA.
Abstract
Abstract:
Hydrogels are an integrated three-dimensional network of water-absorbing hydrophilic
polymers that can support tissue regeneration and release medication under controlled
conditions. Hydrogel-based structures physically resemble the extracellular matrix besides being
effective for biomedical applications and tissue engineering. Hydrogels must provide relevant
biological signals to control the cell behavior to become an ideal bioactive scaffold for tissue
regeneration. Incorporating virus nanoparticles (VNP) that can release essential peptides into the
hydrogels is a promising option to formulate a bioactive scaffold that can facilitate cell proliferation,
adhesion, migration, and differentiation. Over the recent period, virologists have discovered
many viruses that lead to a great understanding of the diversity of viruses in nature. Viruses
affecting the plants are called plant viruses, and they have a wide variety of shapes and sizes, yet
each species produces monodisperse nucleoprotein particles. Plant viruses are not capable of
infecting or reproducing in humans. Therefore, VNPs are engineered from plant viruses whose
genetically programmed structures can be manipulated at the gene level, bioconjugated, or encapsulated.
Plant VNPs can act as clinical diagnostic agents, immunomodulators, medicines,
nanoreactors, and biosensors by displaying protein molecules or epitopes, constructing inorganic
hybrid materials, or carrying molecular charges. The present review focuses on the plant virusmediated
nanoparticles encapsulated in bioactive hydrogels to provide an ideal platform for
tissue engineering.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering,Biotechnology
Cited by
1 articles.
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