Emerging Applications of Polymeric Nanoparticles in Tumor Targeting

Author:

Dureja Harish1ORCID,Marwaha Minakshi Gupta2ORCID,Awasthi Rajendra3ORCID,Marwaha Rakesh Kumar1ORCID,Prasher Parteek45,Gulati Monica6ORCID,Singh Sachin Kumar6ORCID,Anand Krishnan7ORCID,Gupta Gaurav8ORCID,Chellappan Dinesh Kumar9,Dua Kamal101112ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, Haryana, India

2. Faculty of Pharmaceutical Sciences, Baba Mastnath University, Rohtak 124001, Haryana, India

3. Department of Pharmaceutical Sciences, School of Health Sciences & Technology, University of Petroleum and Energy Studies (UPES), Energy Acres, Dehradun 248 007, Uttarakhand, India

4. UGC-Sponsored Centre for Advanced Studies, Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India

5. Department of Chemistry, University of Petroleum & Energy Studies, Energy Acres, Dehradun 248007, India

6. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, Punjab, India

7. Department of Chemical Pathology, School of Pathology, Faculty of Health Sciences and National Health Laboratory Service, University of the Free State, Bloemfontein, South Africa

8. School of Pharmaceutical Sciences, Suresh Gyan Vihar University, Jaipur, Rajasthan, India

9. Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, Malaysia

10. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo NSW 2007, Australia

11. Centenary Institute, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia

12. Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) & School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia

Abstract

Abstract: Nanoparticles are well-established carriers for targeted delivery of bioactive polymeric nanoparticles (PNPs). They have attracted significant attention from pharmaceutical scientists globally due to their wide range of applications in the medical field. The encapsulation of drugs into the nanoparticles offer several unique characteristics leading to prolonged circulation, improved drug localization, and thus enhanced drug efficacy. It also provides a better understanding of the molecular basis of the disease. Nanoparticles allow efficient maintenance of medication cycles at the target site, with less exposure to normal cells and thus decreasing the rehabilitation period. Despite extensive developments in the field of nanotechnology, specifically in drug delivery, only a few nanotechnology-based products are currently available in the market. Thus, further advanced exploration is necessary to make nanoparticles useful for the betterment of mankind. This review is focused on recent advancements in pharmaceutical nanotechnology with special emphasis on polymers used for the preparation of PNPs and their emerging applications in tumor-targeting. This manuscript also highlights on the recent patents disclosing PNPs for tumor targeting.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmaceutical Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering,Biotechnology

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