Affiliation:
1. Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, 22060, Abbottabad, Pakistan
2. Department of Biomedical Sciences, Pak-Austria Fachhochschule: Institute of Applied Sciences and Technology, Mang, Khanpur Road, Haripur, Pakistan
Abstract
Background:
Bacterial cellulose (BC) is the purest form of cellulose as it is free from
pectin, lignin, hemicellulose and other active constituents associated with cellulose derived from
plant sources. High biocompatibility and easy molding into the desired shape make BC an ideal candidate
for applications in the biomedical fields, such as tissue engineering, wound healing and bone
regeneration. In addition to this, BC has been widely studied for applications in the delivery of proteins
and drugs in various forms via different routes. However, BC lacks therapeutic properties and
resistance to the free movement of small molecules, i.e., gases and solvents. Therefore, modification
of BC is required to meet the research ad market demand.
Methods:
We have searched the updated data relevant to as-synthesized and modified BC, properties and applications in
various fields using Web of science, Science direct, Google and PubMed.
Results:
As-synthesized BC possesses properties such as high crystallinity, well organized fibrous network, higher degree
of polymerization, and ability of being produced in swollen form. The large surface area with abundance of free accessible
hydroxyl groups makes BC an ideal candidate for carrying out surface functionalization to enhance its features. The
various reported surface modification techniques including, but not limited to, are amination, methylation and acetylation.
Conclusion:
In this review, we have highlighted various approaches made for BC surface modification. We have also
reported enhancement in the properties of modified BC and potential applications in different fields ranging from
biomedical science to drug delivery and paper-making to various electronic devices.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering,Biotechnology
Cited by
5 articles.
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