Multifunctional Nanoparticles for Organelle-Specific Targeted Drug Delivery in Cancer Therapy

Abstract

Abstract: Successful drug delivery with a carrier into the targeted organelles (nucleus, mitochon-dria, lysosomes, etc.) is vital for achieving effective disease treatment. Nanoparticle (NP) based drug delivery systems (NDDSs) depend on targeted delivery and are mainly focused on cell-membrane targeting. In this review, we summarize research on multifunctional NPs with organelle-specific drug delivery. Different effective strategies are proposed for these nanoparticles functional-izing by altering their chemical composition or by functional groups grafting onto their surface for improving the ability of organelle targeting. Only when the released concentration of drugs be-comes high enough will they interact with specific organelles by molecular targets to induce apop-tosis of tumor cells. One of the prime goals for drug delivery research targeted is Organelle-specific delivery.