Ebola Therapeutic Study and Future Directions
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Published:2019-02-04
Issue:1
Volume:19
Page:17-29
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ISSN:1871-5265
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Container-title:Infectious Disorders - Drug Targets
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language:en
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Short-container-title:IDDT
Author:
Lu Da-Yong1, Wu Hong-Ying2, Yarla Nagendra S.3, Lu Ting-Ren2, Xu Bin4, Jian-Ding 4
Affiliation:
1. School of Life Sciences, Shanghai University, Shanghai, Shanghai 200444, China 2. College of Science, Shanghai University, Shanghai, Shanghai 200444, China 3. GITAM University, Viskhatnam, AP, India 4. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, Shanghai 201203, China
Abstract
The constant Ebola epidemic outbreaks in Africa arisen in waves of panic
worldwide. There is a high mortality rate (30-70%) among the Ebola-infected people in virus-
stricken areas. Despite these horrors, the medical capabilities against this deadly viral
disease were provided by limited therapeutic agents/options. As a result, several patented
agents, biotherapies or prophylactic/therapeutic vaccines need to be reviving into the global
markets—including patents of small molecular chemicals, short sequences or oligomers of
DNA/RNA, linkages of chemicals with bio-molecules, herbal medicine and so on. In addition,
the possible mechanisms of action of these therapeutic options are underway. To promote
Ebola biomedical study, the multiple characters of Ebola infections—its origin, pathologic
progress, genomic changes, therapeutic context and economic considerations are outlined
in this review. Finally, a great difference can be expected after these types of efforts.
Funder
Shanghai Science and Technology Foundation of High Educations
Publisher
Bentham Science Publishers Ltd.
Subject
Microbiology (medical),Pharmacology,Molecular Medicine,General Medicine
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