Affiliation:
1. Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, U.P, India
2. Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, U.P, India
Abstract
Backgrounds:
SARS-CoV-2 infection typically presents with fever and respiratory symptoms.
Besides this, COVID-19-related central and peripheral nervous system manifestations are emerging.
Objectives:
This study summarises the demographics, clinical profiles, laboratory findings, management
strategies, and outcomes in a large number of patients with COVID-19-related GBS and its variants.
We also compared its clinical profile with Zika and dengue virus-related GBS.
Methods:
The authors carried out a literature search up to Dec 31, 2020, in MEDLINE, PubMed,
SCOPUS, Cochrane database, and Google Scholar for all published articles.
Results:
The study identified 54 different types of articles consisting of 70 cases from 17 countries
worldwide. A maximum of 15 cases (21.4 %) were identified from Italy, followed by the USA (12;
17.1 %), Spain (11; 15.7 %), and Iran (10; 14.3 %). The age group that was more than 60 years had the
most cases, i.e., 32 (45.7 %), followed by the age group 40-60 with 25 cases (35.7 %) with a male to
female ratio of 2. Maximum cases were treated with IVIG infusion 58 (82.9 %), followed by Plasma
exchange 13 (18.6 %) cases. Out of 70 cases, 7 (10 %) cases were manifested as Miller-Fisher syndrome.
The most predominant electrodiagnostic variant was demyelinating neuropathy in 41 (73.21 %)
cases. The outcome reported in 67 cases was survival in 63 (90 %) cases and death in 4 (5.7 %) cases.
Conclusion:
Covid-19-related GBS were reported worldwide with a better outcome. Both postinfectious
and parainfectious patterns were reported. Early recognition with prompt management of GBS
can prevent further severe morbidity and mortality.
Publisher
Bentham Science Publishers Ltd.
Subject
Microbiology (medical),Pharmacology,Molecular Medicine,General Medicine
Cited by
5 articles.
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