Affiliation:
1. Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran,Iran
2. National Drug and Alcohol Research Center, University of New South Wales (UNSW), Sydney,Australia
3. Department of Global Health and Socioepidemiology, Graduate School of Medicine, Kyoto University, Kyoto,Japan
Abstract
Background:
HIV can interrupt the normal development of bone marrow cell lines.
Bone marrow aspiration/biopsy (BMA/B) has been described as a diagnostic tool in AIDS patients
with fever of unknown origin (FUO). In this review, we aimed to study patients with AIDS who
had undergone a BMA/B to investigate FUO and describe the pathologies diagnosed in the biopsy.
Methods:
Thirty-four BMA/B samples were collected from AIDS patients admitted for work-up of
FUO to the infectious disease ward of a tertiary referral HIV center in Tehran, Iran, between
September 2014 and September 2015. Data including age, sex, duration of disease, CD4 cell
counts, hepatitis B (HBV) and C (HCV) coinfection, the primary presentation of AIDS, and the
treatment history were retrieved and analyzed. Patients underwent BMA/B. An expert pathologist
reviewed the BMA/B specimens.
Results:
The mean age of the patients was 37.5 years (range, 26-56), and 27 (79%) were men.
Twenty-seven (79%) patients contracted HIV from injection drug use, and 7 (21%) via sexual transmission.
Only 3 (9%) of the BMA/B examinations were normal. Hypocellular bone marrow was diagnosed
in 22 (65%) patients. Other pathologies included granulomas in 6 (18%), hematologic malignancies
in 2 (6%), and leishmaniasis Aspergillosis, each in 1 (3%) patient. Six (17%) of the specimens
were found to have tuberculosis infections.
Conclusion:
Hypocellular bone marrow was the most common pathology on BMA/B examinations,
followed by the presence of granulomas. Tuberculosis, Aspergillosis, and Leishmaniasis the
opportunistic infections diagnosed on BMA/B specimens. Our results support BMA/B as an appropriate
diagnostic tool for early diagnosis of opportunistic infections and malignancies in AIDS.
BMA/B is indispensable in the armament of diagnostic tools of the physicians managing AIDS patients.
Publisher
Bentham Science Publishers Ltd.
Subject
Microbiology (medical),Pharmacology,Molecular Medicine,General Medicine
Cited by
2 articles.
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