Affiliation:
1. Faculty of Pharmacy, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India
Abstract
Introduction:
Epilepsy is a group of chronic neurological disorders characterized by seizures.
Kindling, a chronic epileptic mouse model, was used to explore the epileptogenic mechanism
and seek new anti-epileptics. In kindling, sub-convulsive (chemical/ electrical) stimuli were delivered
repeatedly and erratically, eventually causing massive convulsions. Moreover, Morinda citrifolia (Noni)
extracts are used as a remedy in ayurvedic preparations for many ailments. Noni has recently been
shown to protect mice from amyloid beta-induced memory loss.
Objective:
This study was used to investigate the neuroprotective potential of Morinda citrifolia in
mice over pentylenetetrazol (PTZ)-induced kindling seizure.
Methods:
Kindling was provoked by subsequent (one-day-gap) injections of PTZ (subconvulsive; 35
mg/kg; s.c.) for 29 days in mice. Following PTZ injection, convulsive behaviours were noted for 30
minutes. Forced swimming test (depressive behaviors), elevated plus-maze, and passive avoidance
tests were employed to evaluate cognition. Brain homogenate was used to estimate oxidative stress
(glutathione, superoxide-dismutase, lipid-peroxidation) and acetylcholinesterase activity.
Results:
PTZ-provoked kindled mice displayed depressive behaviors, impaired locomotion, cognitive
dysfunctions and various biochemical changes. However, treatment with Morinda citrifolia extract
(500 and 1000 mg/kg, p.o) and valproic acid (200 mg/kg, p.o) before 60 min of each PTZ injection
diminished kindling scores and restored behavioural, and biochemical changes.
Conclusion:
Our findings suggest Morinda citrifolia offered neuroprotective effects against PTZinduced
kindling seizures in mice, which were established by behavioural and biochemical paradigms.
Publisher
Bentham Science Publishers Ltd.
Subject
Microbiology (medical),Pharmacology,Molecular Medicine,General Medicine
Cited by
1 articles.
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