Therapeutic Potential and Molecular Mechanisms of the Multitargeted Flavonoid Fisetin

Author:

Rauf Abdur1,Abu-Izneid Tareq2,Imran Muhammad3,Hemeg Hassan A.4,Bashir Kashif5,Aljohani Abdullah S.M.6,Aljohani Mona S.M.7,Alhumaydhi Fahad A.8,Khan Ishaq N.9,Bin Emran Talha1011,Gondal Tanweer Aslam12,Nath Nikhil13,Ahmad Ishtiaque14,Thiruvengadam Muthu15

Affiliation:

1. Department of Chemistry, University of Swabi, Anbar, KPK, Pakistan

2. Department of Pharmaceutical Sciences, College of Pharmacy, Al Ain University of Science and Technology, Al Ain Campus, Abu Dhabi, United Arab Emirates

3. Department of Food Science and Technology, University of Narowal, Punjab, Pakistan

4. Department of Medical Laboratory Technology, College of Applied Medical Sciences, Taibah University, P.O. Box 344, Al-Madinah Al-Monawra, 41411, Saudi Arabia

5. Department of Health and Biological Sciences, Abasyn University, Peshawar, Pakistan

6. Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah, Saudi Arabia

7. Pharmaceutical Care Department, King Saud Hospital, Ministry of Health, Unaizah, Saudi Arabia

8. Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia

9. Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, 25100, Pakistan

10. Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, 4381, Bangladesh

11. Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, 1207, Bangladesh

12. School of Exercise and Nutrition, Faculty of Health, Deakin University, Victoria, 3125, Australia

13. Department of Pharmacy, International Islamic University Chittagong, Chittagong, 4318, Bangladesh

14. Department of Dairy Technology, University of Veterinary and Animal Sciences, Lahore, Pakistan

15. Department of Crop Science, College of Sanghuh Life Science, Konkuk University, Seoul, 05029, South Korea

Abstract

Abstract: Flavonoids effectively treat cancer, inflammatory disorders (cardiovascular and nervous systems), and oxidative stress. Fisetin, derived from fruits and vegetables, suppresses cancer growth by altering cell cycle parameters that lead to cell death and angiogenesis without affecting healthy cells. Clinical trials are needed in humans to prove the effectiveness of this treatment for a wide range of cancers. According to the results of this study, fisetin can be used to prevent and treat a variety of cancers. Despite early detection and treatment advances, cancer is the leading cause of death worldwide. We must take proactive steps to reduce the risk of cancer. The natural flavonoid fisetin has pharmacological properties that suppress cancer growth. This review focuses on the potential drug use of fisetin, which has been extensively explored for its cancer-fighting ability and other pharmacological activities such as diabetes, COVID-19, obesity, allergy, neurological, and bone disorders. Researchers have focused on the molecular function of fisetin. In this review, we have highlighted the biological activities against chronic disorders, including cancer, metabolic illnesses, and degenerative illnesses, of the dietary components of fisetin.

Funder

Higher Education Commission of Pakistan

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,General Medicine

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