Application of Biomimetic Nanoparticles based on the Cell Membrane in Tumor Therapy

Abstract

Abstract: Due to their unique biological functionality, nanocarriers can be designed to deliver va-rious anti-tumor drugs in vivo, which has a wide and important application prospect in the field of tumor therapy. However, poor biosafety, short blood circulation time, and weak targeting ability still limit the application of nanoparticles in tumor therapy. In recent years, with the development of biomedicine, the biomimetic technology-based biomembrane-mediated drug delivery system is ex-pected to achieve a breakthrough in tumor-targeted therapy due to low immunogenicity, tumor tar-geting, the adjustability and versatility of intelligent nanocarrier design. This paper mainly reviews the research process of different types of the cell membrane (erythrocyte membrane, cancer cell membrane, bacterial membrane, stem cell membrane, and hybrid membrane)-camouflaged nanopar-ticles in tumor therapy, as well as the challenges and development prospects in clinical application.