Affiliation:
1. Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Mathura, 28146, Uttar
Pradesh, India
Abstract
Abstract:
Depression being a common comorbidity of rheumatoid arthritis (RA) is found to be responsible
for the reduction in the lifespan of the sufferer along with the compromised quality of
life. The study quoted below highlights the pathogenic pathways, the frequency of RA along with
its impact on patients, thus, raising awareness about the concerned topic. It is found that the
chances and frequency of developing depression are 2-3 times higher in patients with RA in comparison
to the general population. For such studies, self-reported questionnaires along with proper
screening of inclusion and exclusion criteria have been employed which helped in a better comparative
study of the topic. As per a report from a meta-analysis, 16.8% of patients with RA have been
observed to develop severe depression. According to recent research in the related field, the hypothesis
of the role of immune-mediated processes and their role in brain networks and inflammation
has been found to be engaged in the progression and pathophysiology of depression in patients
with RA. Autoimmune mechanisms and cytokines are found to play an essential role in coordination
for initiating and sustaining the disorder. Involvement of IL-1, IL-6 and TNF-α has been
studied and analysed widely. A number of studies have shown a connection between depression
and RA-related physical impairment, fatigue, and increased pain. Higher mortality, reduced treatment
compliance, and more comorbidities effects increased suicide risk. It is also found that depression
along with RA leads to hospitalizations, which in turn increase the cost of care for the patient.
Hence, it could be stated that the study of depression in RA can be an important marker for the progression
of RA and its prognosis. The latest treatment strategies for RA include management of
symptoms and early disorder treatment The current review aims to investigate and bring the links
between RA and its symptoms into the limelight, including the psycho-social, physiological, and
neurological aspects along with their molecular mechanism, for a better discernment of the topic
for the readers.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine