Recent Progress in Machine Learning-based Prediction of Peptide Activity for Drug Discovery

Author:

Wu Qihui1,Ke Hanzhong2,Li Dongli1,Wang Qi1,Fang Jiansong1,Zhou Jingwei1

Affiliation:

1. Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China

2. Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, United States

Abstract

Over the past decades, peptide as a therapeutic candidate has received increasing attention in drug discovery, especially for antimicrobial peptides (AMPs), anticancer peptides (ACPs) and antiinflammatory peptides (AIPs). It is considered that the peptides can regulate various complex diseases which are previously untouchable. In recent years, the critical problem of antimicrobial resistance drives the pharmaceutical industry to look for new therapeutic agents. Compared to organic small drugs, peptide- based therapy exhibits high specificity and minimal toxicity. Thus, peptides are widely recruited in the design and discovery of new potent drugs. Currently, large-scale screening of peptide activity with traditional approaches is costly, time-consuming and labor-intensive. Hence, in silico methods, mainly machine learning approaches, for their accuracy and effectiveness, have been introduced to predict the peptide activity. In this review, we document the recent progress in machine learning-based prediction of peptides which will be of great benefit to the discovery of potential active AMPs, ACPs and AIPs.

Funder

Research Fund for Characteristic Innovation Projects of Guangdong Province

National Natural Science Foundation of China

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,General Medicine

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