Affiliation:
1. FioCruz-Fundacao Oswaldo Cruz, Instituto de Tecnologia em Fármacos-Far Manguinhos, Rua Sizenando Nabuco, 100, Manguinhos, 21041-250 Rio de Janeiro-RJ, Brazil
Abstract
Nowadays, tuberculosis (TB) is an important global public health problem, being responsible
for millions of TB-related deaths worldwide. Due to the increased number of cases and resistance of
Mycobacterium tuberculosis to all drugs used for the treatment of this disease, we desperately need new
drugs and strategies that could reduce treatment time with fewer side effects, reduced cost and highly
active drugs against resistant strains and latent disease. Considering that, 4H-1,3-benzothiazin-4-one is a
promising class of antimycobacterial agents in special against TB-resistant strains being the aim of this
review the discussion of different aspects of this chemical class such as synthesis, mechanism of action,
medicinal chemistry and combination with other drugs.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine
Reference41 articles.
1. Zhang Y, Yew WW. Mechanisms of drug resistance in
2. .
3. WHO TB drug resistance types.(Accessed at, http://www.who.int/ tb/areas-of-work/drug-resistant-tb/types/en/
4. .
5. Ginsberg AM. Drugs in development for tuberculosis.
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献