PET Imaging of Adenosine Receptors in Diseases-Reference-Cited by-同舟云学术

PET Imaging of Adenosine Receptors in Diseases

Published:2019-09-16 Issue:16 Volume:19 Page:1445-1463
ISSN:1568-0266
Container-title:Current Topics in Medicinal Chemistry
language:en
Short-container-title:CTMC

Author:

Li Jindian¹,Hong Xingfang²,Li Guoquan¹,Conti Peter S.¹,Zhang Xianzhong³,Chen Kai¹

Affiliation:

1. Department of Radiology, Molecular Imaging Center, Keck School of Medicine, University of Southern California, 2250 Alcazar Street, CSC103, Los Angeles, CA 90033, United States

2. Laboratory of Pathogen Biology, School of Basic Medical Sciences, Dali University, Dali 671000, China

3. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China

Abstract

Adenosine receptors (ARs) are a class of purinergic G-protein-coupled receptors (GPCRs). Extracellular adenosine is a pivotal regulation molecule that adjusts physiological function through the interaction with four ARs: A1R, A2AR, A2BR, and A3R. Alterations of ARs function and expression have been studied in neurological diseases (epilepsy, Alzheimer’s disease, and Parkinson’s disease), cardiovascular diseases, cancer, and inflammation and autoimmune diseases. A series of Positron Emission Tomography (PET) probes for imaging ARs have been developed. The PET imaging probes have provided valuable information for diagnosis and therapy of diseases related to alterations of ARs expression. This review presents a concise overview of various ARs-targeted radioligands for PET imaging in diseases. The most recent advances in PET imaging studies by using ARs-targeted probes are briefly summarized.

Funder

China Scholarship Council (CSC) program

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,General Medicine

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