Chemical Composition, Acetylcholine Esterase and Anti-bacterial Activities of Essential Oils of Elaeosilenum thapsioides (Desf.) Maire from Algeria-Reference-Cited by-同舟云学术

Chemical Composition, Acetylcholine Esterase and Anti-bacterial Activities of Essential Oils of Elaeosilenum thapsioides (Desf.) Maire from Algeria

Published:2021-12-22 Issue:29 Volume:21 Page:2610-2619
ISSN:1568-0266
Container-title:Current Topics in Medicinal Chemistry
language:en
Short-container-title:CTMC

Author:

Barbeche Zakaria¹,Laouer Hocine²,Erenler Ramazan³,Hajji Mohamed⁴,Flamini Guido⁵,Pieracci Ylenia⁵,Khattabi Latifa⁶,Bensouici Chawki⁶,Akkal Salah⁷^ORCID

Affiliation:

1. Exact Sciences Faculty, University Larbi Ben M‘hidi, Oum El Bouaghi 04000, Algeria

2. Laboratory of Natural Resource Valorization, SNV Faculty, Setif 1 University, 19000 Setif, Algeria

3. Department of Chemistry, Faculty of Arts and Sciences, Tokat Gaziosmanpasa University, Tokat, Turkey

4. Laboratory of Enzyme Engineering and Microbiology, National School of Engineers of Sfax, Sfax, Tunisia

5. Dipartimento di Farmacia, Via Bonanno 6, University of Pisa, 56126 Pisa, Italy

6. National Center of Biotechnology Research (CRBT), Constantine, Algeria

7. Department of Chemistry, Valorization of Natural Resources, Bioactive Molecules and Biological Analysis Unit, University of Mentouri Constantine1, 25000, Constantine, Algeria

Abstract

Background: Traditionally, the Algerian medicinal plant Elaeosilenum thapsioides (Desf.) Maire has been used for many diseases. The present research work aims to explore the chemical and biological characterization of its essential oil. Methods : The essential oils were obtained by hydrodistillation of different Elaeosilenum thapsioides (Apiaceae) aerial parts samples collected from two different regions (Mahouane and Megres) from Setif, Eastern Algeria. The chemical characterization of the obtained essential oils is reported here for the first time. Besides, they were evaluated for their in vitro Acetylcholinesterase (AChE) inhibitory activity involved in Alzheimer’s disease using Ellman’s spectrophotometric method. Results: Additionally, their in vitro antimicrobial activity was assessed by the disc diffusion method. Both activities were performed at various oil concentrations. The GC/MS analysis of the essential oils from aerial parts (leaves, stems, flowers, and seeds) of E. thapsioides identified 47 constituents. Monoterpene hydrocarbons were the main components, ranging from 72.78 to 99.13%. Oxygenated monoterpenes and oxygenated sesquiterpenes ranged between 1.37 and 17.25% and 0.12 and 3.53% in essential oils from leaves and stems. Sesquiterpene hydrocarbons were present in small to large quantities in the essential oils of both populations, ranging from 0.69 to 13.44%. The presence of m-Methoxybenzyl isothiocyanate was recorded in stems essential oils from Mahouane and leaves essential oils from Merges, which was 9.73% and 3.72%, respectively. Conclusion: The stems essential oils obtained from plants collected in Mahouane showed the highest AChE inhibitory activity. The highest anti-bacterial activity was shown by the essential oil obtained from Megres leaves against Bacillus cereus ATCC 11778. The oils exhibited a moderate inhibitory activity in both tests.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,General Medicine