Prodrug Strategies in the CNS Drugs: Small Modification Makes Big Improvements
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Published:2021-09
Issue:24
Volume:21
Page:2157-2169
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ISSN:1568-0266
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Container-title:Current Topics in Medicinal Chemistry
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language:en
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Short-container-title:CTMC
Author:
Kang Ting1,
Miao Zhuang1,
Liu Siyu1,
Ke Bowen1
Affiliation:
1. Laboratory of Anesthesia and Critical Care Medicine, Department of Anesthesiology, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
Abstract
Prodrug design is an effective method proven to improve the drug-like properties of a molecule,
and it has been widely used in the drug development of various diseases. Due to the complexity
of the central nervous system (CNS), the development of CNS drugs has high requirements related to
the pharmaceutical, pharmacokinetic, and pharmacodynamic properties of the molecules. Prodrug
design has now been widely and successfully applied to improve these properties. We conducted a
mini-review to promote the use of the prodrug strategies in CNS drug development. To facilitate the
description, we chose drug indications as a clue, then presented and discussed some representative
CNS prodrugs. Finally, a brief summary and outlook about this area were presented.
Funder
1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University
Chengdu Science and Technology Program
Sichuan Science and Technology Program
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine
Cited by
2 articles.
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