1,3,4-Oxadiazoles as Potential Pharmacophore for Cytotoxic Potentiality: A Comprehensive Review-Reference-Cited by-同舟云学术

1,3,4-Oxadiazoles as Potential Pharmacophore for Cytotoxic Potentiality: A Comprehensive Review

Published:2021-10-07 Issue:15 Volume:21 Page:1377-1397
ISSN:1568-0266
Container-title:Current Topics in Medicinal Chemistry
language:en
Short-container-title:CTMC

Author:

Sharma Divya¹,Salahuddin ¹,Sharma Vikas¹,Kumar Rajnish¹,Joshi Sagar¹,Kumari Sunita¹,Saxena Shivani¹,Mazumder Avijit¹,Yar Mohammad Shahar²,Ahsan Mohamed Jawed³

Affiliation:

1. Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, KP-2, Greater Noida, Uttar Pradesh-201306, India

2. Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard University, Hamdard Nagar, New Delhi-110062, India

3. Department of Pharmaceutical Chemistry, Maharishi Arvind College of Pharmacy, Ambabari Circle, Jaipur, Rajasthan- 302039, India

Abstract

Cancer is a kind of human cell degenerative disease that has affected many people for several years. Cancer is caused due to the abnormal growth of cells in every particular part of the body. The 1,3,4-oxadiazole ring is found to be a binding moiety that has anticancer potential. Various works on the 1,3,4-oxadiazole moiety showing anticancer activity have been reported. The present analysis summarizes general synthetic methods for 1,3,4 oxadiazole. Different receptors on which these drug acts are discussed. This review also presents pharmacophore models for topoisomerase-I, histone deacetylase, and epidermal growth factor enzymes.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,General Medicine

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