Advances in Metal-organic Frameworks (MOFs) based Biosensors for Diagnosis: An Update

Abstract

Abstract: Metal-organic frameworks (MOFs) have significant advantages over other candidate classes of chemo-sensory materials owing to their extraordinary structural tunability and character-istics. MOF-based biosensing is a simple and convenient method for identifying various species. Biomarkers are molecular or cellular processes that link environmental exposure to a health out-come. Biomarkers are important in understanding the links between environmental chemical expo-sure and the development of chronic diseases, as well as in identifying disease-prone subgroups. Until now, several species, including nanoparticles (NPs) and their nanocomposites, small mole-cules, and unique complex systems, have been used for the chemical sensing of biomarkers. Follow-ing the overview of the field, we discussed the various fabrication methods for MOFs development in this review. We provide a thorough overview of the previous five years of progress to broaden the scope of analytes for future research. Several enzymatic and non-enzymatic sensors are offered, together with a mandatory measuring method that includes detection range and dynamic range. In addition, we reviewed the comparison of enzymatic and non-enzymatic biosensors, inventive edges, and the difficulties that need to be solved. This work might open up new possibilities for material production, sensor development, medical diagnostics, and other sensing fields.