A Review on Aptamers Selection and Application in Heart Diseases Diagnosis-Reference-Cited by-同舟云学术

A Review on Aptamers Selection and Application in Heart Diseases Diagnosis

Published:2022-11 Issue:30 Volume:22 Page:2463-2473
ISSN:1568-0266
Container-title:Current Topics in Medicinal Chemistry
language:en
Short-container-title:CTMC

Author:

Marty Jean Louis¹^ORCID,Rhouati Amina²^ORCID,Rhouati Adel³^ORCID

Affiliation:

1. BAE laboratory, Perpignan University, Perpignan, 66680, France

2. Bioengineering Laboratory, Higher National School of Biotechnology, Constantine 25100-Algeria

3. Cardiology Department, Ibn Badis University Hospital, University of Constantine 3, Constantine, Algeria

Abstract

Abstract: Biomarkers detection and quantification in biological fluids play a key role in the screen-ing, diagnosing and treating several diseases. Recently, a large number of aptamers have been selected and applied for the sensing of different biomarkers. Combined with different transducers, aptamers provide simple and rapid tools that allow highly sensitive and selective detection. Cardiol-ogy requires an accurate assessment of cardiac biomarkers for a complete diagnosis of cardiovascu-lar diseases. The analysis is generally performed by immunoassays using antibodies as biorecogni-tion elements. This review paper focuses on using aptamers as a promising alternative for antibodies in cardiac biomarkers biosensing. First, the different aptamers specific to the most important cardiac biomarkers are Troponin I, the peptide of B-type natriuretic peptide and myoglobin. Then, in the second part, we overview the electrochemical aptasensors principle and characteristics reported in the literature in the last five years.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,General Medicine

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