Medicinal Chemistry Strategies Towards SO2 Donors as Research Tools and Potential Therapeutics

Abstract

SO₂ is emerging as a possible endogenous signaling molecule in mammals. In addition, SO₂ has also shown pharmacological effects, presenting SO₂ as a promising potential therapeutic agent. The past decade has witnessed steady advances in the development of small molecule-based SO₂ prodrugs/donors with varied release mechanisms. Herein, we summarize various strategies employed for SO₂ prodrug design. The remaining challenges and issues will also be discussed.