Affiliation:
1. Research Committee Member, Pharmacy Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Department of Microbiology, Medicine Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Department of Pharmacognosy, Pharmacy Faculty, Ardabil University of Medical Sciences, Ardabil, Iran
4. Evidencebased Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran
Abstract
Phytochemicals are the most valuable and comprehensive structures, which may have a
broad range of protective benefits, from reducing inflammation and speeding healing to preventing
infection and fighting cancer. Resveratrol (RSV) is a natural phenolic compound from the oligomeric
stilbenoids group, which is usually found in daily human diet, such as grape, peanut, berries and
grains. It exhibits anti-inflammatory, neuroprotective, antioxidant, and cancer prevention and treatment
effects. RSV is thought to have an impressive outcome in colorectal cancer (CRC) treatment
through the vital molecules and cancer signaling pathways, including SIRT1, P53, P21, AMPK, ROS,
BMP7, COX-2, NO, caspases, Wnt, TNFs, NF-κB, EMT, and pentose phosphate pathway. Therefore,
this paper reviews the current researches on the pharmacological effects and pharmacokinetics of
resveratrol and its drug delivery system, as well as clinical studies involving CRC.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine
Cited by
30 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献