Phenylamino-pyrimidine (PAP) Privileged Structure: Synthesis and Medicinal Applications-Reference-Cited by-同舟云学术

Phenylamino-pyrimidine (PAP) Privileged Structure: Synthesis and Medicinal Applications

Published:2020-03-18 Issue:3 Volume:20 Page:227-243
ISSN:1568-0266
Container-title:Current Topics in Medicinal Chemistry
language:en
Short-container-title:CTMC

Author:

Ferreira Pimentel Luiz Claudio¹^ORCID,Cunha Anna Claudia²^ORCID,Boas Hoelz Lucas Villas¹^ORCID,Canzian Henayle Fernandes¹^ORCID,Leite Firmino Marinho Debora Inacio¹^ORCID,Boechat Nubia¹^ORCID,Bastos Monica Macedo¹^ORCID

Affiliation:

1. Fundacao Oswaldo Cruz, Instituto de Tecnologia em Farmacos, Farmanguinhos - Fiocruz, Laboratório de Sintese de Farmacos - LASFAR, Manguinhos, CEP 21041-250, Rio de Janeiro, RJ, Brazil

2. Universidade Federal Fluminense, Departamento de Quimica Organica, Campus do Valonguinho, CEP 24020-150, Niteroi, RJ, Brazil

Abstract

The phenylamino-pyrimidine (PAP) nucleus has been demonstrated to be useful for the development of new drugs and is present in a wide variety of antiretroviral agents and tyrosine kinase inhibitors (TKIs). This review aims to evaluate the application of PAP derivatives in drugs and other bioactive compounds. It was concluded that PAP derivatives are still worth exploring, as they may provide highly competitive ATP TKI’s with nano/picomolar activity.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,General Medicine

Reference110 articles.

1. Brown D.J.; Mason S.F.; The pyrimidines 2009

2. Rewcastle G.W.; Denny, W. A.; Showalter, H. D. H. Synthesis of 4-(phenylamino)pyrimidine derivatives as ATP-competitive Protein kinase inhibitors with potential for cancer chemotherapy. Curr Org Chem 2000,4,679-706

3. Kumar P.R.L.; Gautam G.; Synthesis and anti inflammatory activity of 3-(2-4-methyl-2-(2-nitrophenylamino)-6-(piperazin-1-yl methyl) pyrimidin-5-yl)-2H-chromen-2-one. World J Pharm Pharm Sci 2018,7(11),1410-1417

4. Zimmerman J.; Buchdunger E.; Mett H.; Meyer T.; Lydon N.B.; Potent and selective inhibitors of the Abl-kinase: phenylamino-pyrimidine (PAP) derivatives. Bioorg Med Chem Lett 1997,7(2),187-192

5. Basford F.R.; Curd F.H.; Rose F.L.; Openshaw H.; Hull R.T.; Todd A.R.; Pyrimidine Compounds. U.S. Patent 2,465,568, March 291949

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