Affiliation:
1. Shandong Key Laboratory of Biophysics, Institute of Biophysics, Dezhou University, Dezhou 253023, Shandong,China
2. School of Life Sciences, Dezhou University, Dezhou 253023, Shandong,China
Abstract
Indole, a heterocyclic organic compound, is one of the most promising heterocycles found in
natural and synthetic sources since its derivatives possess fascinating structural diversity and various
therapeutic properties. Indole alkaloids, synthetic dimers and hybrids could act on diverse targets in
cancer cells, and consequently, possess potential antiproliferative effects on various cancers both in
vitro and in vivo. Vinblastine, midostaurin, and anlotinib as the representative of indole alkaloids, synthetic
dimers and hybrids respectively, have already been clinically applied to treat many types of cancers,
demonstrating indole alkaloids, synthetic dimers and hybrids are useful scaffolds for the development
of novel anticancer agents. Covering articles published between 2010 and 2020, this review emphasizes
the recent development of indole alkaloids, synthetic dimers and hybrids with potential in vivo
therapeutic application for cancers.
Funder
Natural Science Foundation of Anhui Province
National Natural Science Foundation of China
Taishan Young Scholars Program of Shandong Province
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine
Reference196 articles.
1. Siegel R.L.; Miller K.D.; Jemal A.; Cancer statistics, 2020. CA Cancer J Clin 2020,70(1),7-30
2. International Agency for Research on Cancer. Latest global cancer
data: Cancer burden rises to 18.1 million new cases and 9.6 million
cancer deaths in 2018 2019 Available from: https://www.iarc.fr/wp-content/uploads/2018/09/pr263_E.pdf
3. Dagenais G.R.; Leong D.P.; Rangarajan S.; Lanas F.; Lopez-Jaramillo P.; Gupta R.; Diaz R.; Avezum A.; Oliveira G.B.F.; Wielgosz A.; Parambath S.R.; Mony P.; Alhabib K.F.; Temizhan A.; Ismail N.; Chifamba J.; Yeates K.; Khatib R.; Rahman O.; Zatonska K.; Kazmi K.; Wei L.; Zhu J.; Rosengren A.; Vijayakumar K.; Kaur M.; Mohan V.; Yusufali A.; Kelishadi R.; Teo K.K.; Joseph P.; Yusuf S.; Variations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE): a prospective cohort study. Lancet 2020,395(10226),785-794
4. Hulvat M.C.; Cancer incidence and trends. Surg Clin North Am 2020,100(3),469-481
5. Zahedipour F.; Jamialahmadi K.; Karimi G.; The role of noncoding RNAs and sirtuins in cancer drug resistance. Eur J Pharmacol 2020,877
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