Affiliation:
1. Division of Applied Biomedical Science and Biotechnology, School of Health Science, International Medical University, Kuala Lumpur, Malaysia
2. School of Biosciences, Faculty of Health & Medical Sciences, Taylor's University, Selangor, Malaysia
Abstract
Parkinson’s disease is a common neurodegenerative disease affecting the movement and
well-being of most elderly. The manifestations of Parkinson’s disease often include resting tremor,
stiffness, bradykinesia, and muscular rigidity. The typical hallmark of Parkinson’s disease is the destruction
of neurons in the substantia nigra and the presence of Lewy bodies in different compartments
of the central nervous system. Due to various limitations to the currently available treatments,
immunotherapies have emerged to be the new approach to Parkinson’s disease treatment.
This approach shows some positive outcomes on the efficacy by removing the aggregated species
of alpha-synuclein, which is believed to be one of the causes of Parkinson’s disease. In this review,
an overview of how alpha-synuclein contributes to Parkinson’s disease and the effects of a few
new immunotherapeutic treatments, including BIIB054 (cinpanemab), MEDI1341, AFFITOPE,
and PRX002 (prasinezumab) that are currently under clinical development, will be discussed.
Funder
Ministry of Higher Education, Malaysia
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,General Neuroscience
Reference101 articles.
1. Olanow C.W.; Klein C.; Schapira A.H.V.; Harrison’s principles of internal medicine 2019,1-24
2. DeMaagd G.; Philip A.; Parkinson’s disease and its management: Part 1: Disease entity, risk factors, pathophysiology, clinical presentation, and diagnosis. P 2015,40(8),504-532
3. Bridi J.C.; Hirth F.; Mechanisms of α-Synuclein induced synaptopathy in parkinson’s disease. Front Neurosci 2018,12(2),80
4. Willard A.M.; Isett B.R.; Whalen T.C.; Mastro K.J.; Ki C.S.; Mao X.; Gittis A.H.; State transitions in the substantia nigra reticulata predict the onset of motor deficits in models of progressive dopamine depletion in mice. ELife 2019,8,1-27
5. Braak H.; Sastre M.; Bohl J.R.E.; de Vos R.A.; Del Tredici K.; Parkinson’s disease: Lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre- and postganglionic neurons. Acta Neuropathol 2007,113(4),421-429
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