Affiliation:
1. Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh,India
Abstract
:
Human Central Nervous System (CNS) is the complex part of the human body, which
regulates multiple cellular and molecular events taking place simultaneously. Parkinsons Disease
(PD) is the second most common neurodegenerative disease after Alzheimer’s disease (AD). The
pathological hallmarks of PD are loss of dopaminergic neurons in the substantianigra (SN) pars
compacta (SNpc) and accumulation of misfolded α-synuclein, in intra-cytoplasmic inclusions
called Lewy bodies (LBs). So far, there is no cure for PD, due to the complexities of molecular
mechanisms and events taking place during the pathogenesis of PD. Drosophila melanogaster is an
appropriate model organism to unravel the pathogenicity not only behind PD but also other NDs.
In this context as numerous biological functions are preserved between Drosophila and humans.
Apart from sharing 75% of human disease-causing genes homolog in Drosophila, behavioral responses
like memory-based tests, negative geotaxis, courtship and mating are also well studied.
The genetic, as well as environmental factors, can be studied in Drosophila to understand the geneenvironment
interactions behind the disease condition. Through genetic manipulation, mutant flies
can be generated harboring human orthologs, which can prove to be an excellent model to understand
the effect of the mutant protein on the pathogenicity of NDs.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,General Neuroscience
Cited by
4 articles.
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