Voltage-gated Sodium Channels in Sensory Information Processing-Reference-Cited by-同舟云学术

Voltage-gated Sodium Channels in Sensory Information Processing

Published:2019-07-17 Issue:4 Volume:18 Page:273-278
ISSN:1871-5273
Container-title:CNS & Neurological Disorders - Drug Targets
language:en
Short-container-title:CNSNDDT

Author:

Zhou You¹,Pan Ping¹,Tan Zhi-Yong²,Ji Yong-Hua¹

Affiliation:

1. Laboratory of Neuropharmacology and Neurotoxicology, Shanghai University, Shanghai 200444, China

2. Department of Pharmacology and Toxicology and Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, United States

Abstract

Objective & Background: Voltage-gated sodium channels (VGSCs) and potassium channels are critical in the generation of action potentials in the nervous system. VGSCs and potassium channels play important roles in the five fundamental senses of vision, audition, olfaction, taste and touch. Dysfunctional VGSCs are associated with clinical sensory symptoms, such as hyperpselaphesia, parosphresia, and so on. Conclusion: This short review highlights the recent advances in the study of VGSCs in sensory information processing and discusses the potential role of VGSCs to serve as pharmacological targets for the treatment of sensory system diseases.

Funder

Indiana Spinal Cord and Brain Injury Research grant from the Indiana State Department of Health

National Natural Science Foundation of China

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,General Neuroscience

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