Role of BDNF signaling in the neuroprotective and memory-enhancing effects of flavonoids in Alzheimer’s Disease

Abstract

Introduction: Foods rich in flavonoids are associated with a reduced risk of various chronic diseases, including Alzheimer's disease (AD). In fact, growing evidence suggests that consuming flavonoid-rich foods can beneficially affect normal cognitive function. Animal models have shown that many flavonoids prevent the development of AD-like pathology and improve cognitive deficits. Result: Flavonoid-rich foods, such as green tea and blueberries, must exert their effect through the direct interaction of absorbed flavonoids and their metabolites with cellular and molecular targets. Conclusion: Based on the most recent scientific literature, this review article critically examines the therapeutic role of dietary flavonoids in ameliorating and preventing the progression of AD and focuses on the role of the BDNF signaling pathway in the neuroprotective effects of flavonoids.